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| Abstract |
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| Title: | The prion protein and cellular cholesterol homeostasis. |
| Author: | Luisa Diomede ; Gianluigi Forloni ; Orso Bugiani ; Fabrizio Tagliavini ; Mario Salmona |
| Abstract: | The amount of lipids in cell membranes seems to regulate the interaction of the prion protein with cells and the propagation of prions. We investigated how the synthetic human prion peptide PrP 106-126 affected the chemico-physical and biochemical properties of nerve and HL60 cells. PrP 106-126 rapidly increased cell membrane microviscosity, inhibited cellular cholesterol release and increased membrane cholesterol content. PrP also inhibited cellular 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. These findings indicate that PrP 106-126 alters cellular cholesterol homeostasis and may help clarify how changes in membrane lipid composition are involved in the progression of prion encephalopathies. |
| Journal: | Neurobiology of Lipids |
| Issn: | 16835506 |
| EIssn: | |
| Year: | 2002 |
| Volume: | 1 |
| Issue: | |
| pages/rec.No: | 8-14 |
| Key words | Prion protein ; PrP 106-126 ; 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase ; membrane fluidity ; cell homeoviscosity ; etiology ; lipids ; learning ; memory ; lipoprotein ; receptor ; LTP ; neurodegeneration marker ; oxidative stress ; PHF NFT tau phosphorylation ; phospholipids ; synaptic plasticity ; disease ; therapy ; nutrition ; cytoskeleton ; Down syndrome ; prions ; scrapie |
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