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| Abstract |
Year: 1997 Volume: 30 - Issue: 4
| Title: | Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol |
| Author: | Saad W.A. ; Luiz A.C. ; Camargo L.A.A. ; Silveira J.E.N. ; Fóglia S. ; Menani J.V. ; Saad William A. |
| Abstract: | We investigated the effects of losartan, an AT1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/1 µl) into the LV blocked the pressor response induced by ANG II (12 ng/1 µl) and carbachol (2 nmol/1 µl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/1 µl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure |
| Journal: | Brazilian Journal of Medical and Biological Research |
| Issn: | 0100879X |
| EIssn: | 00347310 |
| Year: | 1997 |
| Volume: | 30 |
| Issue: | 4 |
| pages/rec.No: | 493-496 |
| Key words | pressor response ; central angiotensin ; carbachol |
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