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| Abstract |
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| Title: | Abnormal cholesterol processing in Alzheimer's disease patient's fibroblasts |
| Author: | Franck Dufour ; Wei-Qin Zhao ; Lakshmi Ravindranath ; Daniel L. Alkon |
| Abstract: | Cholesterol has recently received attention as a potentially important factor in Alzheimer's disease (AD) etiology. Caveolin, which binds cholesterol, plays a prominent role in cellular cholesterol transport. Here, we found a higher level of cholesterol and caveolin in the caveolae-enriched fractions prepared from AD patients' fibroblasts compared with age and sex matched controls (AC). Furthermore, the cross-linking activation of the prion protein, which is known to link to signal transduction of caveolin, is altered in AD fibroblasts. Our results suggest a dysregulation of cholesterol processing in AD fibroblasts which may contribute to the pathogenesis of AD. |
| Journal: | Neurobiology of Lipids |
| Issn: | 16835506 |
| EIssn: | |
| Year: | 2003 |
| Volume: | 1 |
| Issue: | |
| pages/rec.No: | 34-45 |
| Key words | Alzheimer's disease ; amyloid beta precursor ; APP ; Down syndrome ; etiology ; lipids ; lipoprotein ; neurodegeneration marker ; secretase ; caveolin ; caveolae ; membrane ; cell culture ; human ; non-neuronal tissue ; neurodegenerative disease ; signal transduction ; prion ; PKC ; cross-linking ; fractioning ; biochemistry ; triton |
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