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QTc interval prolongation in HIV-infected patients: a case–control study by 24-hour Holter ECG recording

BMC Cardiovascular Disorders. 2012;12(1):124 DOI 10.1186/1471-2261-12-124


Journal Homepage

Journal Title: BMC Cardiovascular Disorders

ISSN: 1471-2261 (Online)

Publisher: BMC

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML



Fiorentini Alessandra

Petrosillo Nicola

Di Stefano Angelo

Cicalini Stefania

Borgognoni Laura

Boumis Evangelo

Tubani Luigi

Chinello Pierangelo


Open peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 19 weeks


Abstract | Full Text

<p>Abstract</p> <p>Background</p> <p>Aim of the study was to assess QTc interval by a 24-hour ECG recording in a group of HIV-infected individuals with a basal prolonged QTc. The risk factors associated with QTc prolongation and the indices of cardiovascular autonomic control were also evaluated.</p> <p>Methods</p> <p>A case–control study was performed using as cases 32 HIV-infected patients with prolonged (>440 msec) QTc interval as assessed by Holter ECG, and as controls 64 HIV-infected subjects with normal QTc interval. Autonomic function was evaluated by heart rate variability analysis during 24-hour recording.</p> <p>Results</p> <p>Duration of HIV disease was significantly longer among cases than among controls (p=0.04). Waist/hip ratio was also higher among cases than among controls (p=0.05). Frequency domain analysis showed the absence of physiologic decrease of low frequency (LF) in the night period in both cases and controls. The LF night in cases showed a statistically significant reduction when compared with controls (p=0.007).</p> <p>Conclusions</p> <p>In our study group, QTc interval prolongation was associated with a longer duration of HIV infection and with a greater waist/hip ratio. HIV patients with QTc interval prolongation and with a longer duration of HIV infection were more likely to have an impairment of parasympathetic and sympathetic cardiac component.</p>