In this study, in order to follow the heart signals of patients that needs to be monitored instantly and continuously without mobility restrictions, a portable electrocardiogram circuit is designed. After performing the detection, upgrading, cleaning and digitizing of ECG signal received from patient via disposable electrodes, ECG signals was performed that transmit to a central node with Wireless Sensor Network (WSN) based on ZigBee 802.11.4 standard. Central node is connected to the serial port of a computer. Received data from the central node is processed on computer and continuous flow graph is obtained. The obligation to use wires for tracing patients’ ECG has been removed with this portable system. As it can be seen in this study, thanks to WSN’s property of forming network by itself and its augmentable loop property, the restrain of ECG signals to reach far away distances can be surmounted. The transmission of biological signals with WSN will light on many studies that follow of patients from a distance.