eNeurologicalSci (Sep 2025)
Antecedent sedative use is independently associated with stroke occurrence among west Africans: Evidence from the SIREN case-control study
- Ezinne O. Uvere,
- Joshua Akinyemi,
- Fred S. Sarfo,
- Adekunle Fakunle,
- Akinkunmi Paul Okekunle,
- Onoja Akpa,
- Albert Akpalu,
- Kolawole Wahab,
- Reginald Obiako,
- Morenikeji Komolafe,
- Lukman Owolabi,
- Godwin O. Osaigbovo,
- Godwin Ogbole,
- Hemant K. Tiwari,
- Carolyn Jenkins,
- Samuel Olowookere,
- Oyedunni Arulogun,
- Josephine Akpalu,
- Osahon J. Asowata,
- Philip Ibinaiye,
- Cynthia Akisanya,
- Olalekan I. Oyinloye,
- Lambert Appiah,
- Atinuke M. Agunloye,
- Abiodun M. Adeoye,
- Joseph Yaria,
- Daniel T. Lackland,
- Donna Arnett,
- Ruth Y. Laryea,
- Benedict Calys-Tagoe,
- Okechukwu S. Ogah,
- Mayowa Ogunronbi,
- Suleiman Y. Isah,
- Hamisu A. Dambatta,
- Raelle Tagge,
- Olayemi Balogun,
- Obiageli U. Agbogu-Ike,
- Rufus Akinyemi,
- Bruce Ovbiagele,
- Mayowa Owolabi
Affiliations
- Ezinne O. Uvere
- Department of Medicine, University of Ibadan, Nigeria; Department of Health Promotion and Education, University of Ibadan, Nigeria
- Joshua Akinyemi
- Department of Epidemiology and Medical Statistics, University of Ibadan, Nigeria
- Fred S. Sarfo
- Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.; Corresponding author.
- Adekunle Fakunle
- Department of Public Health, Osun State University, Osogbo, Nigeria
- Akinkunmi Paul Okekunle
- Department of Epidemiology and Medical Statistics, University of Ibadan, Nigeria
- Onoja Akpa
- Department of Epidemiology and Medical Statistics, University of Ibadan, Nigeria
- Albert Akpalu
- Department of Medicine, University of Ghana Medical School, Accra, Ghana.
- Kolawole Wahab
- Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
- Reginald Obiako
- Department of Medicine, Ahmadu Bello University, Zaria, Nigeria.
- Morenikeji Komolafe
- Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria
- Lukman Owolabi
- Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
- Godwin O. Osaigbovo
- Jos University Teaching Hospital Jos, Nigeria
- Godwin Ogbole
- Department of Radiology, University of Ibadan, Nigeria
- Hemant K. Tiwari
- University of Alabama at Birmingham, Birmingham, AL, USA
- Carolyn Jenkins
- Medical University of South Carolina, USA
- Samuel Olowookere
- Federal Medical Centre, Abeokuta, Nigeria.
- Oyedunni Arulogun
- Department of Health Promotion and Education, University of Ibadan, Nigeria
- Josephine Akpalu
- Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
- Osahon J. Asowata
- Department of Epidemiology and Medical Statistics, University of Ibadan, Nigeria
- Philip Ibinaiye
- Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
- Cynthia Akisanya
- Federal Medical Centre, Abeokuta, Nigeria.
- Olalekan I. Oyinloye
- Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria
- Lambert Appiah
- Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
- Atinuke M. Agunloye
- Department of Medicine, University of Ibadan, Nigeria
- Abiodun M. Adeoye
- Department of Medicine, University of Ibadan, Nigeria; Department of Medicine, University College Hospital, Ibadan, Nigeria
- Joseph Yaria
- Department of Medicine, University College Hospital, Ibadan, Nigeria
- Daniel T. Lackland
- Medical University of South Carolina, USA
- Donna Arnett
- College of Public Health, University of Kentucky, KY, USA
- Ruth Y. Laryea
- Department of Medicine, University of Ghana Medical School, Accra, Ghana.
- Benedict Calys-Tagoe
- College of Public Health, University of Kentucky, KY, USA
- Okechukwu S. Ogah
- Department of Medicine, University of Ibadan, Nigeria
- Mayowa Ogunronbi
- Federal Medical Centre, Abeokuta, Nigeria.
- Suleiman Y. Isah
- Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
- Hamisu A. Dambatta
- Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
- Raelle Tagge
- Weill Institute for Neurosciences, School of Medicine, University of California San Francisco, USA
- Olayemi Balogun
- Department of Medicine, Ahmadu Bello University, Zaria, Nigeria.
- Obiageli U. Agbogu-Ike
- Department of Medicine, Ahmadu Bello University, Zaria, Nigeria.
- Rufus Akinyemi
- Department of Medicine, University of Ibadan, Nigeria; Federal Medical Centre, Abeokuta, Nigeria.; Center for Genomic and Precision Medicine, University of Ibadan, Nigeria
- Bruce Ovbiagele
- Weill Institute for Neurosciences, School of Medicine, University of California San Francisco, USA
- Mayowa Owolabi
- Department of Medicine, University of Ibadan, Nigeria; Department of Medicine, University College Hospital, Ibadan, Nigeria; Center for Genomic and Precision Medicine, University of Ibadan, Nigeria; Blossom Specialist Medical Center, Ibadan, Nigeria; Corresponding author at: Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria, University College Hospital Ibadan and Blossom Specialist Medical Center, Ibadan, Nigeria.
- Journal volume & issue
-
Vol. 40
p. 100573
Abstract
Background: Several factors have been independently associated with stroke occurrence globally. However, the association between sedative use and stroke risk is yet to be established in West Africa. Objective: To assess the association between sedatives and stroke among West Africans. Methods: Adults aged ≥18 years with confirmed stroke as well as age- and sex-matched controls were enrolled into the Stroke Investigative Research and Education Network (SIREN) study. Sedative use was determined by retrospective assessment on the use of any type of sedative in the preceding year while stroke was confirmed with brain scan and clinical features. Univariate and multivariate analyses, using logistic regressions, were performed to establish associations between sedative use and stroke while adjusting for other stroke risk factors. Results: A total of 7104 subjects (3553 stroke cases and 3551 stroke-free controls participated in this study. The mean age was 60.9 ± 0.78 among cases and 59.8 ± 11.44 years among controls (p $100, history of hypertension, diabetes, dyslipidaemia, tobacco & alcohol use, physical inactivity, green leafy vegetable and meat consumption, sedative use was independently associated with stroke risk (aOR: 1.41; 95 %CI: 1.01–1.96; p < 0.041). Sedative use was associated with higher odds of stroke among adults aged ≥50 years (aOR: 1.53; 95 %CI: 1.28–2.04; p < 0.019). Conclusion: Sedative use was independently associated with stroke risk among adults in West Africa. Its use requires further exploration and prospective study to address the emerging association with stroke occurrence.
