Introduction: There are many classical cardiac risk factors leading to acute coronary syndromes (ACS): arterial hypertension (HA), diabetes mellitus (DM), lipid disorders, family history (FH), smoking (Sm), obesity. The one of risk stratification is an evaluation of biochemical cardiac markers demonstrating myocardial injury. Material and methods: The studied group included 124 patients (27% females, mean age 60.5±11.1 years) hospitalized with symptoms of ACS. In all patients the level of cardiac troponin T (cTnT) was measured in admission. In the case of a negative result a measurement was repeated after 6-12 hours. According to results the patients were stratified into: group 1 – with negative (<0.1 µg/L) and group 2 – with positive (³0.1 µg/L) cTnT concentrations. In these groups results of coronarography and selected classical cardiac risk factors were analyzed. Results: The performance of: HA, Sm, FH, obesity and lipid profile was similar. The percentage of critical single and multivessel coronary stenoses did not differentiate both groups. In patients with a positive cTnT in comparison to the cTnT negative group diabetes, and the critical stenoses of the circumflex coronary artery (p<0.05) occurred more often. In diabetics with the positive cTnT compared to non-diabetics of group 2 frequently the elevated concentration of triglycerides (p<0.01) and the overweight in comparison to diabetics of the 1 group (p<0.05) were documented. Conclusions: In patients with acute coronary syndrome and a positive cTnT diabetes occurs more often compared to the cTnT negative patients. Diabetics belong to the group of high risk, so they require a detailed diagnosis and treatment.