The 10,000 Immunomes Project: Building a Resource for Human Immunology
Kelly A. Zalocusky,
Matthew J. Kan,
Zicheng Hu,
Patrick Dunn,
Elizabeth Thomson,
Jeffrey Wiser,
Sanchita Bhattacharya,
Atul J. Butte
Affiliations
Kelly A. Zalocusky
Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA
Matthew J. Kan
Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA
Zicheng Hu
Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA
Patrick Dunn
Information Systems Health IT, Northrop Grumman, Rockville, MD 20850, USA
Elizabeth Thomson
Information Systems Health IT, Northrop Grumman, Rockville, MD 20850, USA
Jeffrey Wiser
Information Systems Health IT, Northrop Grumman, Rockville, MD 20850, USA
Sanchita Bhattacharya
Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA
Atul J. Butte
Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA; Corresponding author
Summary: There is increasing appreciation that the immune system plays critical roles not only in the traditional domains of infection and inflammation but also in many areas of biology, including tumorigenesis, metabolism, and even neurobiology. However, one of the major barriers for understanding human immunological mechanisms is that immune assays have not been reproducibly characterized for a sufficiently large and diverse healthy human cohort. Here, we present the 10,000 Immunomes Project (10KIP), a framework for growing a diverse human immunology reference, from ImmPort, a publicly available resource of subject-level immunology data. Although some measurement types are sparse in the presently deposited ImmPort database, the extant data allow for a diversity of robust comparisons. Using 10KIP, we describe variations in serum cytokines and leukocytes by age, race, and sex; define a baseline cell-cytokine network; and describe immunologic changes in pregnancy. All data in the resource are available for visualization and download at http://10kimmunomes.org/. : Zalocusky et al. report the development of a data resource comprising curated, integrated, and normalized immunology measurements from all healthy normal human subjects in the ImmPort database.
