To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of 1H NMR, 13C NMR, and ESI-HRMS. All the compounds were evaluated for their anti-inflammatory activity towards BV2 cell lines using L-NMMA (IC50 = 42.36 ± 2.47 µM) as a positive control. Most showed good anti-inflammatory activities, especially compounds 10 (IC50 = 8.40 ± 0.98 µM), 15 (IC50 = 10.74 ± 2.67 µM), 16 (IC50 = 10.96 ± 1.85 µM), and 17 (IC50 = 9.76 ± 1.27 µM), which exhibited potent anti-inflammatory effects on BV2 cell lines.
