Química Nova (Jan 2009)

Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)

  • Fernando Rogério Pavan,
  • Clarice Queico Fujimura Leite,
  • Roberta Gomes Coelho,
  • Isabel Duarte Coutinho,
  • Neli Kika Honda,
  • Claudia Andréa Lima Cardoso,
  • Wagner Vilegas,
  • Sergio Roberto de Andrade Leite,
  • Daisy Nakamura Sato

DOI
https://doi.org/10.1590/S0100-40422009000500026
Journal volume & issue
Vol. 32, no. 5
pp. 1222 – 1226

Abstract

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The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.

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