Clinico-pharmacological characteristics of opioid drug-drug interactions in cancer patients with chronic pain syndrome

Abstract

The aim of the review was to analyze published studies on the impact of opioid drug-drug interactions on the choice of analgesic therapy regimens.Material and methods. A systematic literature search was conducted using PubMed, Scopus, Web of Science, and E-library databases.Results. The review showed a clinical significance of pharmacokinetic interactions of opioids with other drugs in cancer pain treatment. The problems of individual choice of analgesics from different groups under conditions of co-morbidity and concomitant medication were discussed to ensure the effectiveness/safety of the treatment strategy affecting the quality of life of cancer patients.Conclusion. A comprehensive assessment of factors in patients receiving opioid analgesics is a predictor of effective and safe analgesic therapy.

Keywords

• drug interactions
• opioids
• chronic pain syndrome
• comorbidity
• malignant neoplasms
• analgesics
• drug therapy
• antidepressants
• tamoxifen
• antimycotics