Treating recurrent aphthous stomatitis with oral mucoadhesive films containing chitosan: a clinical randomized controlled study

Abstract

Objective To study the efficacy and safety of oral mucoadhesive containing chitosan for the treatment of recurrent aphothous stomatitis (RAS).Methods 72 subjects, who were diagnosed with RAS, were involved in the study. The subjects were randomly allocated to the test or control group and shown how to use the films. The film containing chitosan was provided to the participants in the test group and the polyvinyl alcohol film was provided to the control group. Baseline, pain score (visual analog scale), ulcer size and adverse effects were recorded.Results The reduction in ulcer size was significantly greater (P 0.05). No obvious adverse effects were observed. Conclusion The oral mucoadhesive film containing chitosan promotes healing of RAS.

Keywords

• recurrent aphthous stomatitis，
• chitosan，
• polyvinyl alcohol，
• film ，
• clinical controlled study，
• ulcer healing，