Impact of COVID-19 Vaccination on Cardiac Function and Survival in Maintenance Hemodialysis Patients
Xiao Tu,
Tingfei He,
Bing Xu,
Jiazhen Yin,
Fangyu Yi,
Ye Li,
Jinchi Gao,
Peng Bi,
Wanyue Xu,
Rihong Hu,
Lidan Hu,
Yayu Li
Affiliations
Xiao Tu
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, #453 Tiyu Road, Xihu District, Hangzhou 310012, China
Tingfei He
Hangzhou Clinical College, Zhejiang Chinese Medical University, #548 Binwen Road, Hangzhou 310053, China
Bing Xu
Hangzhou Clinical College, Zhejiang Chinese Medical University, #548 Binwen Road, Hangzhou 310053, China
Jiazhen Yin
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, #453 Tiyu Road, Xihu District, Hangzhou 310012, China
Fangyu Yi
Hangzhou Clinical College, Zhejiang Chinese Medical University, #548 Binwen Road, Hangzhou 310053, China
Ye Li
Hangzhou Clinical College, Zhejiang Chinese Medical University, #548 Binwen Road, Hangzhou 310053, China
Jinchi Gao
Hangzhou Clinical College, Zhejiang Chinese Medical University, #548 Binwen Road, Hangzhou 310053, China
Peng Bi
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, #453 Tiyu Road, Xihu District, Hangzhou 310012, China
Wanyue Xu
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, #453 Tiyu Road, Xihu District, Hangzhou 310012, China
Rihong Hu
Hemodialysis Unit, Hangzhou Hospital of Traditional Chinese Medicine, #453 Tiyu Road, Xihu District, Hangzhou 310012, China
Lidan Hu
Department of Nephrology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Binjiang District, Hangzhou 310003, China
Yayu Li
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, #453 Tiyu Road, Xihu District, Hangzhou 310012, China
Maintenance hemodialysis patients are at increased risk of cardiovascular complications and mortality following COVID-19 infection due to compromised immune function. This study aims to evaluate the impact of the COVID-19 vaccine (CoronaVac) on cardiac function and survival in this population. Background/Objectives: We aimed to examine whether CoronaVac vaccination affects heart function and survival rates in maintenance hemodialysis patients. Specifically, we assessed changes in heart ultrasound (echocardiographic) measurements, B-type natriuretic peptide (BNP) levels, and survival outcomes by comparing vaccinated and unvaccinated patients. Methods: A retrospective analysis was conducted on 531 maintenance hemodialysis patients, including 79 who received CoronaVac and 452 who did not. We compared the pre- and post-infection changes in heart function (echocardiographic parameters) and BNP levels between the two groups and assessed their association with the survival rates. Results: The vaccinated patients were younger (60.54 ± 13.51 vs. 65.21 ± 13.76 years, p = 0.006) and had shorter dialysis durations (56.04 ± 51.88 vs. 73.73 ± 64.79 months, p = 0.022). The mortality rate was also significantly lower in the vaccinated group (6.33% vs. 14.38%, p = 0.049). After infection, the unvaccinated patients showed significant declines in heart function and increased B-type natriuretic peptide levels, while the vaccinated patients demonstrated no significant deterioration. Older age, coronary artery disease, inflammation levels, and heart abnormalities were identified as the key risk factors for mortality. Conclusions: CoronaVac was linked to lower mortality and better heart function in maintenance hemodialysis patients. The vaccine may help to reduce infection severity, lower strain on the heart, and improve the overall prognosis.
