Expert consensus-based recommendations on the use of photodynamic therapy in actinic keratosis patientsCapsule Summary

Vishal A. Patel, MD; Sarah T. Arron, MD; Brian Berman, MD, PhD; M. Shane Chapman, MD, MBA; Anokhi Jambusaria-Pahlajani, MD; George Martin, MD; Anthony M. Rossi, MD; Todd Schlesinger, MD; Nathalie C. Zeitouni, MDCM; Neal Bhatia, MD

doi:10.1016/j.jdin.2024.11.011

JAAD International (Jun 2025)

Expert consensus-based recommendations on the use of photodynamic therapy in actinic keratosis patientsCapsule Summary

Vishal A. Patel, MD,
Sarah T. Arron, MD,
Brian Berman, MD, PhD,
M. Shane Chapman, MD, MBA,
Anokhi Jambusaria-Pahlajani, MD,
George Martin, MD,
Anthony M. Rossi, MD,
Todd Schlesinger, MD,
Nathalie C. Zeitouni, MDCM,
Neal Bhatia, MD

Affiliations

Vishal A. Patel, MD: Department of Dermatology, George Washington University School of Medicine & Health Sciences, Washington, District of Columbia
Sarah T. Arron, MD: Peninsula Dermatology, Burlingame, California
Brian Berman, MD, PhD: University of Miami Miller School of Medicine, Miami, Florida; Center for Clinical and Cosmetic Research, Aventura, Florida
M. Shane Chapman, MD, MBA: Department of Dermatology, Dartmouth Hitchcock Medical Center, Nashua, New Hampshire; Geisel School of Medicine at Dartmouth, Lebanon and Hanover, New Hampshire
Anokhi Jambusaria-Pahlajani, MD: Division of Dermatology, Department of Internal Medicine, The University of Texas at Austin Dell Medical School, Austin, Texas
George Martin, MD: Dr. George Martin Dermatology Associates, Kihei, Hawaii
Anthony M. Rossi, MD: Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York; New York Presbyterian Hospital, New York, New York
Todd Schlesinger, MD: Clinical Research Center of the Carolinas, Charleston, South Carolina
Nathalie C. Zeitouni, MDCM: Medical Dermatology Specialists, Phoenix, Arizona; University of Arizona COM, Phoenix, Arizona
Neal Bhatia, MD: Therapeutics Clinical Research, San Diego, California; Correspondence to: Dr Neal Bhatia, MD, Therapeutics Clinical Research, 9025 Balboa Ave, Suite 105, San Diego, CA 92123.

DOI: https://doi.org/10.1016/j.jdin.2024.11.011
Journal volume & issue: Vol. 20
pp. 62 – 73

Abstract

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Background: Current actinic keratosis (AK) treatment guidelines are controversial and incomplete, leaving an unmet need for clearer and more in-depth guidance on the usage of photodynamic therapy (PDT) in AKs. Objective: To gain consensus on the use of PDT for AKs using a modified Delphi method. Methods: Consensus statements were developed after a literature review of topics surrounding PDT and AKs. Ten panelists voted through electronic questionnaires rating each statement on a three-point Likert-type scale: strongly agree, agree, and disagree. Consensus was established when ≥70% of panelists strongly agreed on the statement. Statements that did not meet the threshold were revised after each round of voting and sent out for the next round of voting. A virtual meeting was held after 2 rounds of voting to discuss outstanding statements. Results: Three modified Delphi rounds were completed in total and 1 virtual meeting was held. All 10 experts responded to all rounds of voting. A total of 55 statements established consensus with the ≥70% majority requirement necessary. Limitations: Recommendations are based on expert opinions. Conclusion: The results from this consensus panel are intended to bridge gaps in the existing guidelines and will continue to evolve.

Published in JAAD International

ISSN: 2666-3287 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Dermatology
Website: https://www.journals.elsevier.com/jaad-international

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