Effects of ω-3 Fatty Acid Supplementation on Glycemic Status and Hhigh Sensitive C-Reactive Protein in Women with Polycystic Ovary Syndrome

Abstract

Background & Objectives: Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders among females. PCOS is associated with development of type 2 diabetes and cardiovascular disease. The objectives of this study were to determine the effects of omega-3 fatty acids on glycemic status and high sensitive C-reactive protein in women with PCOS. Methods: This double-blind randomized controlled clinical trial was conducted on 61 PCOS patients. Subjects in ω-3 fatty acids (n=30) and placebo (n=31) groups take 4 ω-3 fatty acids capsules (each one contained 180 mg eicosapentaenoic acid and 120 mg docosahexanoic acid) or placebo daily for 8 weeks. Anthropometric and biochemical measurments and food intakes were assessed at the beginning and at the end of the study. Results: ω-3 fatty acid supplementation caused significant decrease in serum levels of glucose, insulin (p 0.05). Conclusion: ω-3 fatty acid supplementation had some beneficial effects on glycemic status of PCOS patients and may be useful in prevention and control of metabolic conmplication of this syndrome.

Keywords

• Polycystic Ovary Syndrome; ω-3 Fatty Acids; Glycemic Status; High Sensitive C-Reactive Protein