Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes
Kundalkesha D. Gaikwad,
Panchsheela Ubale,
Rahul Khobragade,
Sachin Deodware,
Pratibha Dhale,
Mahadev R. Asabe,
Rekha M. Ovhal,
Pranav Singh,
Prashant Vishwanath,
Chandan Shivamallu,
Raghu Ram Achar,
Ekaterina Silina,
Victor Stupin,
Natalia Manturova,
Ali A. Shati,
Mohammad Y. Alfaifi,
Serag Eldin I. Elbehairi,
Shashikant H. Gaikwad,
Shiva Prasad Kollur
Affiliations
Kundalkesha D. Gaikwad
Department of Chemistry, Sangameshawar College, Solapur 413 001, India
Panchsheela Ubale
Department of Chemistry, N. K. Orchid College of Engineering and Technology, Solapur 413 002, India
Rahul Khobragade
Department of Microbiology, Dr. Babasaheb Ambedkar Marathwada University, Sub Campus, Osmanabad 413 501, India
Sachin Deodware
Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Solapur 413 411, India
Pratibha Dhale
Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Solapur 413 411, India
Mahadev R. Asabe
Department of Chemistry, Walchand College of Art and Science, Solapur 413 006, India
Rekha M. Ovhal
Department of Chemistry, Walchand College of Art and Science, Solapur 413 006, India
Pranav Singh
Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Udupi 576 104, India
Prashant Vishwanath
Centre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570 015, India
Chandan Shivamallu
Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570 015, India
Raghu Ram Achar
Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570 015, India
Ekaterina Silina
Department of Hospital Surgery, N.I. Pirogov Russian National Research Medical University, Moscow 117997, Russia
Victor Stupin
Department of Hospital Surgery, N.I. Pirogov Russian National Research Medical University, Moscow 117997, Russia
Natalia Manturova
Department of Hospital Surgery, N.I. Pirogov Russian National Research Medical University, Moscow 117997, Russia
Ali A. Shati
Biology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia
Mohammad Y. Alfaifi
Biology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia
Serag Eldin I. Elbehairi
Biology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia
Shashikant H. Gaikwad
Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Solapur 413 411, India
Shiva Prasad Kollur
School of Physical Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru 570 026, India
The present work describes the chemical preparation of Schiff bases derived from 4,4′-diaminodiphenyl sulfone (L1–L5) and their Co(II) metal complexes. The evaluation of antimicrobial and anticancer activities against MCF-7 cell line and human lung cancer cell line A-549 was performed. The aforementioned synthesized compounds are characterized by spectroscopic techniques and elemental analysis confirms successful synthesis. The results from the above analytical techniques revealed that the complexes are in an octahedral geometry. The antimicrobial activity of the synthesized Schiff base ligands and their metal complexes under study was carried out by using the agar well diffusion method. The ligand and complex interactions for biological targets were predicted using molecular docking and high binding affinities. Further, the anticancer properties of the synthesized compounds are performed against the MCF-7 cell line and human lung cancer cell line A-549 using adriamycin as the standard drug.
