Unanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogel

Abstract

This study evaluated the cytotoxicity of fusidic acid-loaded HA hydrogels on different cell types. Results show significant cytotoxicity, especially at concentrations above 0.1 %, with MC3T3 cells being the most sensitive. These findings highlight the importance of considering cell-specific responses and cytotoxic effects when designing antibiotic-loaded hydrogels for biomedical applications.

Keywords

• Antibiotics
• Fusidic acid
• Cytotoxicity
• Cell viability
• Cell apoptosis