DYSFUNCTION OF IMMUNE RESPONSE REGULATION AS A FUNDAMENTAL CAUSE OF AUTOIMMUNITY ONSET

Abstract

Aim: To investigate the types of immune response regulation and immunological tolerance disorders in autoimmune diseases. Methods: Bibliometric indicators` analysis of scientific articles and analytical materials from databases such as Scopus, Web of Science, DOAJ, and PubMed were used. Results. The most important types of regulation of the immune response, which are disturbed in autoimmune diseases, are the withdrawal of immunological tolerance to self-antigens (in which cellular and cytokine types of regulation become unbalanced) and genetic type. It analyzed the consequences of dysregulation of cellular, cytokine, genetic, idiotypic-anti-idiotypic, and immune-neuroendocrine types, which cause a breakage of immunological tolerance and the start of autoaggression. Conclusions. The consequences of dysregulation of the immune response, which causes the reversal of immunological tolerance, create the ground on which numerous autoimmune reactions quickly form into an autoimmune syndrome and become autoimmune diseases.

Keywords

• immune response
• immunological tolerance
• tregs
• autoreactive b cells
• apoptotic cells.