Schizophrenia (Jun 2025)
The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures
- Daniel H. Mathalon,
- Spero Nicholas,
- Brian J. Roach,
- Tashrif Billah,
- Suzie Lavoie,
- Thomas Whitford,
- Holly K. Hamilton,
- Lauren Addamo,
- Andrey Anohkin,
- Tristan Bekinschtein,
- Aysenil Belger,
- Kate Buccilli,
- John Cahill,
- Ricardo E. Carrión,
- Stefano Damiani,
- Ilvana Dzafic,
- Bjørn H. Ebdrup,
- Igor Izyurov,
- Johanna Jarcho,
- Raoul Jenni,
- Anna Jo,
- Sarah Kerins,
- Clarice Lee,
- Elizabeth A. Martin,
- Rocio Mayol-Troncoso,
- Margaret A. Niznikiewicz,
- Muhammad Parvaz,
- Oliver Pogarell,
- Julio Prieto-Montalvo,
- Rachel Rabin,
- David R. Roalf,
- Jack Rogers,
- Dean F. Salisbury,
- Riaz Shaik,
- Stewart Shankman,
- Michael C. Stevens,
- Yi Nam Suen,
- Nicole C. Swann,
- Xiaochen Tang,
- Judy L. Thompson,
- Ivy Tso,
- Julian Wenzel,
- Juan Helen Zhou,
- Jean Addington,
- Luis Alameda,
- Celso Arango,
- Nicholas J. K. Breitborde,
- Matthew R. Broome,
- Kristin S. Cadenhead,
- Monica E. Calkins,
- Rolando I. Castillo-Passi,
- Eric Yu Hai Chen,
- Jimmy Choi,
- Philippe Conus,
- Cheryl M. Corcoran,
- Barbara A. Cornblatt,
- Covadonga M. Diaz-Caneja,
- Lauren M. Ellman,
- Paolo Fusar-Poli,
- Pablo A. Gaspar,
- Carla Gerber,
- Louise Birkedal Glenthøj,
- Leslie E. Horton,
- Christy Lai Ming Hui,
- Joseph Kambeitz,
- Lana Kambeitz-Ilankovic,
- Matcheri S. Keshavan,
- Minah Kim,
- Sung-Wan Kim,
- Nikolaos Koutsouleris,
- Jun Soo Kwon,
- Kerstin Langbein,
- Daniel Mamah,
- Vijay A. Mittal,
- Merete Nordentoft,
- Godfrey D. Pearlson,
- Jesus Perez,
- Diana O. Perkins,
- Albert R. Powers,
- Fred W. Sabb,
- Jason Schiffman,
- Jai L. Shah,
- Steven M. Silverstein,
- Stefan Smesny,
- William S. Stone,
- Gregory P. Strauss,
- Rachel Upthegrove,
- Swapna K. Verma,
- Jijun Wang,
- Daniel H. Wolf,
- Tianhong Zhang,
- Sylvain Bouix,
- Ofer Pasternak,
- Kang-Ik K. Cho,
- Michael J. Coleman,
- Dominic Dwyer,
- Angela Nunez,
- Zailyn Tamayo,
- Stephen J. Wood,
- Rene S. Kahn,
- John M. Kane,
- Patrick D. McGorry,
- Carrie E. Bearden,
- Barnaby Nelson,
- Scott W. Woods,
- Martha E. Shenton,
- Accelerating Medicines Partnership® Schizophrenia Program,
- Gregory A. Light
Affiliations
- Daniel H. Mathalon
- Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California San Francisco
- Spero Nicholas
- Mental Health Service, Veterans Affairs San Francisco Health Care System
- Brian J. Roach
- Mental Health Service, Veterans Affairs San Francisco Health Care System
- Tashrif Billah
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Suzie Lavoie
- Orygen
- Thomas Whitford
- Orygen
- Holly K. Hamilton
- Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California San Francisco
- Lauren Addamo
- Orygen
- Andrey Anohkin
- Washington University School of Medicine
- Tristan Bekinschtein
- Consciousness and Cognition Lab, Department of Psychology, University of Cambridge
- Aysenil Belger
- Department of Psychiatry, University of North Carolina at Chapel Hill
- Kate Buccilli
- Orygen
- John Cahill
- Department of Psychiatry, Yale University School of Medicine
- Ricardo E. Carrión
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- Stefano Damiani
- Department of Brain and Behavioral Sciences, University of Pavia
- Ilvana Dzafic
- Orygen
- Bjørn H. Ebdrup
- Centre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health Centre
- Igor Izyurov
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- Johanna Jarcho
- Department of Psychology & Neuroscience, Temple University
- Raoul Jenni
- Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne (CHUV-UNIL)
- Anna Jo
- Department of Psychiatry, Chonnam National University Medical School
- Sarah Kerins
- Early Psychosis Detection and Clinical Intervention (EPIC) lab, Department of Psychosis Studies, King’s College
- Clarice Lee
- Orygen
- Elizabeth A. Martin
- Department of Psychological Science, University of California
- Rocio Mayol-Troncoso
- Department of Psychiatry, IMHAY, University of Chile
- Margaret A. Niznikiewicz
- Harvard Medical School
- Muhammad Parvaz
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Oliver Pogarell
- Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich
- Julio Prieto-Montalvo
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense
- Rachel Rabin
- PEPP-Montreal, Douglas Research Centre
- David R. Roalf
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Jack Rogers
- Institute for Mental Health, University of Birmingham
- Dean F. Salisbury
- Department of Psychiatry, University of Pittsburgh School of Medicine
- Riaz Shaik
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Stewart Shankman
- Department of Psychiatry and Behavioral Sciences, Northwestern University
- Michael C. Stevens
- Department of Psychiatry, Yale University School of Medicine
- Yi Nam Suen
- School of Nursing, LKS Faculty of Medicine, University of Hong Kong
- Nicole C. Swann
- Department of Human Physiology, University of Oregon
- Xiaochen Tang
- Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine
- Judy L. Thompson
- Departments of Psychiatry and Neuroscience, University of Rochester Medical Center
- Ivy Tso
- Department of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center
- Julian Wenzel
- Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Juan Helen Zhou
- Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore
- Jean Addington
- Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary
- Luis Alameda
- General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP–Lausanne), Lausanne University Hospital and University of Lausanne
- Celso Arango
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense
- Nicholas J. K. Breitborde
- Department of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center
- Matthew R. Broome
- Institute for Mental Health, University of Birmingham
- Kristin S. Cadenhead
- Department of Psychiatry, University of California
- Monica E. Calkins
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Rolando I. Castillo-Passi
- Department of Psychiatry, IMHAY, University of Chile
- Eric Yu Hai Chen
- Department of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong
- Jimmy Choi
- Olin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health Network
- Philippe Conus
- General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP–Lausanne), Lausanne University Hospital and University of Lausanne
- Cheryl M. Corcoran
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Barbara A. Cornblatt
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- Covadonga M. Diaz-Caneja
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense
- Lauren M. Ellman
- Department of Psychology & Neuroscience, Temple University
- Paolo Fusar-Poli
- Department of Brain and Behavioral Sciences, University of Pavia
- Pablo A. Gaspar
- Department of Psychiatry, IMHAY, University of Chile
- Carla Gerber
- Prevention Science Institute, University of Oregon
- Louise Birkedal Glenthøj
- Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen
- Leslie E. Horton
- Department of Psychiatry, University of Pittsburgh School of Medicine
- Christy Lai Ming Hui
- Department of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong
- Joseph Kambeitz
- Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Lana Kambeitz-Ilankovic
- Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich
- Matcheri S. Keshavan
- Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School
- Minah Kim
- Department of Neuropsychiatry, Seoul National University Hospital
- Sung-Wan Kim
- Department of Psychiatry, Chonnam National University Medical School
- Nikolaos Koutsouleris
- Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich
- Jun Soo Kwon
- Department of Psychiatry, Hanyang University Hospital
- Kerstin Langbein
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- Daniel Mamah
- Department of Psychiatry, Washington University Medical School
- Vijay A. Mittal
- Department of Psychology, Northwestern University
- Merete Nordentoft
- Department of Clinical Medicine, University of Copenhagen
- Godfrey D. Pearlson
- Department of Psychiatry, Yale University School of Medicine
- Jesus Perez
- CAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust
- Diana O. Perkins
- Department of Psychiatry, University of North Carolina at Chapel Hill
- Albert R. Powers
- Department of Psychiatry, Yale University School of Medicine
- Fred W. Sabb
- Prevention Science Institute, University of Oregon
- Jason Schiffman
- Department of Psychological Science, University of California
- Jai L. Shah
- Department of Psychiatry, McGill University
- Steven M. Silverstein
- Departments of Psychiatry and Neuroscience, University of Rochester Medical Center
- Stefan Smesny
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- William S. Stone
- Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School
- Gregory P. Strauss
- Department of Psychology, University of Georgia
- Rachel Upthegrove
- Institute for Mental Health, University of Birmingham
- Swapna K. Verma
- Institute of Mental Health
- Jijun Wang
- Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine
- Daniel H. Wolf
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Tianhong Zhang
- Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine
- Sylvain Bouix
- Department of Software Engineering and Information Technology, École de technologie supérieure
- Ofer Pasternak
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Kang-Ik K. Cho
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Michael J. Coleman
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Dominic Dwyer
- Orygen
- Angela Nunez
- Department of Psychiatry, Yale University School of Medicine
- Zailyn Tamayo
- Department of Psychiatry, Yale University School of Medicine
- Stephen J. Wood
- Orygen
- Rene S. Kahn
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- John M. Kane
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- Patrick D. McGorry
- Orygen
- Carrie E. Bearden
- Department of Psychological Science, University of California
- Barnaby Nelson
- Orygen
- Scott W. Woods
- Department of Psychiatry, Yale University School of Medicine
- Martha E. Shenton
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Accelerating Medicines Partnership® Schizophrenia Program
- Gregory A. Light
- Department of Psychiatry, University of California
- DOI
- https://doi.org/10.1038/s41537-025-00622-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Abstract Individuals at clinical high risk for psychosis (CHR) have variable clinical outcomes and low conversion rates, limiting development of novel and personalized treatments. Moreover, given risks of antipsychotic drugs, safer effective medications for CHR individuals are needed. The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Program was launched to address this need. Based on past CHR and schizophrenia studies, AMP SCZ assessed electroencephalography (EEG)-based event-related potential (ERP), event-related oscillation (ERO), and resting EEG power spectral density (PSD) measures, including mismatch negativity (MMN), auditory and visual P300 to target (P3b) and novel (P3a) stimuli, 40-Hz auditory steady state response, and resting EEG PSD for traditional frequency bands (eyes open/closed). Here, in an interim analysis of AMP SCZ EEG measures, we assess test-retest reliability and stability over sessions (baseline, month-2 follow-up) in CHR (n = 654) and community control (CON; n = 87) participants. Reliability was calculated as Generalizability (G)-coefficients, and changes over session were assessed with paired t-tests. G-coefficients were generally good to excellent in both groups (CHR: mean = 0.72, range = 0.49–0.85; CON: mean = 0.71, range = 0.44–0.89). Measure magnitudes significantly (p < 0.001) decreased over session (MMN, auditory and visual target P3b, visual novel P3a, 40-Hz ASSR) and/or over runs within sessions (MMN, auditory/visual novel P3a and target P3b), consistent with habituation effects. Despite these small systematic habituation effects, test-retest reliabilities of the AMP SCZ EEG-based measures are sufficiently strong to support their use in CHR studies as potential predictors of clinical outcomes, markers of illness progression, and/or target engagement or secondary outcome measures in controlled clinical trials. Watch Dr Daniel H. Mathalon discuss their work and this article: https://vimeo.com/1066564687 .
