Effect of High-Intensity Interval Training and Dietary Approaches to Stop Hypertension on Oocyte Reserve Biomarker and Insulin Resistance in Obese Women With Polycystic Ovary Syndrome

Abstract

Introduction: Polycystic ovary syndrome (PCOS), as an underlying factor associated with reproductive problems, has a high prevalence in obese women. Therefore, the present study aimed to determine the effect of high-intensity interval training (HIIT) and the Dietary Approaches to Stop Hypertension (DASH) diet on biomarkers of oocyte reserve and insulin resistance in obese women with PCOS. Materials and methods: A total of 40 obese women with PCOS were randomly divided into four groups: control, DASH diet, interval training, and interval training+DASH diet. The HIIT was performed for eight weeks (three sessions in a week are performed in supervised forms, and two sessions in a week are performed in unsupervised forms). Diet groups followed the DASH diet for eight weeks. Anti-Müllerian (AMH) and homeostasis model assessment of insulin resistance (HOMA-IR) index were measured before and 48 h after the last training session and healthy diet. The analysis of data was performed using the factor analysis of variance test at a significance level of P<0.05. Results: The effect of HIIT exercise (F=0.27; P=0.15) and DASH diet (F=0.16; P=0.69) alone and the effect of exercise×diet (F=1.07; P=0.33) on AMH level were not significant. However, the HIIT exercise (F=26.7; P=0.001) and DASH diet (F=100.1; P=0.0001) alone and exercise×diet (F=45.8; P=0.001) significantly reduced insulin resistance. Conclusion: It seems that HIIT exercise (P=0.15) and DASH diet (P=0.69) are not effective for the reduction of the AMH hormone; however, HIIT and DASH can be used to improve insulin resistance in obese women with PCOS.

Keywords

• anti-müllerian (amh) hormone
• dash diet
• high-intensity interval training (hiit)
• insulin resistance
• polycystic ovary syndrome (pcos)