Frontiers in Neuroscience (May 2025)
Neural adaptations to temporal cues degradation in early blind: insights from envelope and fine structure vocoding
Abstract
In our previous study, early-blind individuals have better speech recognition than sighted individuals, even when the spectral cue was degraded using noise-vocoders. Therefore, this study investigated the impact of temporal envelope degradation and temporal fine structure (TFS) degradation on vocoded speech recognition and cortical auditory response in early blind individuals compared to sighted individuals. The study included 20 early-blind subjects (31.20 ± 42.5 years, M: F = 11:9), and 20 age- and -sex-matched sighted subjects. Monosyllabic words were processed using the Hilbert transform to separate the envelope and TFS, generating vocoders that included only one of these components. The amplitude modulation (AM) vocoder, which contained only the envelope component, had the low-pass filter's cutoff frequency for AM extraction set at 16, 50, and 500 Hz to control the amount of AM cue. The frequency modulation (FM) vocoders, which contained only the TFS component, were adjusted to include FM cues at 50%, 75%, and 100% by modulating the noise level. A two-way repeated measures ANOVA revealed that early-blind subjects outperforming sighted subjects across almost all AM or FM-vocoded conditions (p < 0.01). Speech recognition in early-blind subjects declined more with increasing TFS degradation, as evidenced by a significant interaction between group and the degree of TFS degradation (p = 0.016). We also analyzed neural responses based on the semantic oddball paradigm using the N2 and P3b components, which occur 200–300 ms and 250–800 ms after stimulus onset, respectively. Significant correlations were observed between N2 and P3b amplitude/latency and behavioral accuracy (p < 0.05). This suggests that early-blind subjects may develop enhanced neural processing strategies for temporal cues. In particular, preserving TFS cues is considered important for the auditory rehabilitation of individuals with visual or auditory impairments.
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