Polish Journal of Pathology (Oct 2024)

The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome

  • Ewa Dobak,
  • Sylwia Romana Jankowska-Szabłowska,
  • Renata Guzicka-Kazimierczak,
  • Paulina Poter,
  • Elżbieta Urasińska,
  • Katarzyna Karpińska-Łukaszewicz

DOI
https://doi.org/10.5114/pjp.2024.143228
Journal volume & issue
Vol. 75, no. 3
pp. 182 – 191

Abstract

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The normal subpopulation of CD34+CD38 – haematopoietic stem cells does not express CLL-1; therefore, the assessment of the expression of this protein can be used for the diagnosis of minimal residual disease. The aim of this study was to evaluate, using multi-colour flow cytometry, the level of CLL-1 protein expression on CD34+CD38- myeloid niche cells in acute myeloid leukaemia (AML) and myelodysplastic syndromepatients at the time of diagnosis and during disease monitoring on the example of 3 practical cases. The following conclusion was drawn: CD34+CD38-CLL-1+ cells in AML patients may serve as a biomarker to predict disease aggressiveness.

Keywords