Pulmonology (Dec 2025)
Daily digital biomarkers in the follow-up and clustering of patients with asthma
- Bernardo Sousa-Pinto,
- Florence Schleich,
- Gilles Louis,
- Bilun Gemicioglu,
- Violeta Kvedarienė,
- Frederico S. Regateiro,
- Claudia Chaves Loureiro,
- Luis Taborda-Barata,
- Rita Amaral,
- Josep M. Antó,
- Anna Bedbrook,
- Wienczyslawa Czarlewski,
- Ignacio J. Ansotegui,
- Karl-C Bergmann,
- Matteo Bonini,
- Apostolos Bossios,
- Louis-Philippe Boulet,
- Fulvio Braido,
- Christopher Brightling,
- Guy Brusselle,
- Luisa Brussino,
- G. Walter Canonica,
- Alvaro A. Cruz,
- Tari Haahtela,
- Liam G. Heaney,
- Michael Hyland,
- Juan Carlos Ivancevich,
- Ludger Klimek,
- Marek Kulus,
- Piotr Kuna,
- Maciej Kupczyk,
- Desiree E. Larenas-Linnemann,
- Michael Makris,
- Manuel Marques-Cruz,
- Sara Gil-Mata,
- Mário Morais-Almeida,
- Marek Niedoszytko,
- Markus Ollert,
- Nikolaos G. Papadopoulos,
- Vincenzo Patella,
- Oliver Pfaar,
- Celeste Porsbjerg,
- Francesca Puggioni,
- Santiago Quirce,
- Carlos Robalo Cordeiro,
- Nicolas Roche,
- Boleslaw Samolinski,
- Joaquin Sastre,
- Nicola Scichilone,
- Sabina Skrgat,
- Sanna Toppila-Salmi,
- Omar S. Usmani,
- Arunas Valiulis,
- Brigita Gradauskiene,
- Ilgim Vardaloğlu Koyuncu,
- Maria Teresa Ventura,
- Rafael José Vieira,
- Arzu Yorgancioglu,
- João A. Fonseca,
- Torsten Zuberbier,
- Benoit Pétré,
- Renaud Louis,
- Jean Bousquet
Affiliations
- Bernardo Sousa-Pinto
- MEDCIDS – Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
- Florence Schleich
- Department of Pulmonary Medicine, CHU Liège, Liège, Belgium
- Gilles Louis
- GIGA I3 Research Group, University of Liège, Liège, Belgium
- Bilun Gemicioglu
- Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Istanbul, Turkey
- Violeta Kvedarienė
- Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
- Frederico S. Regateiro
- Allergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal
- Claudia Chaves Loureiro
- Coimbra Institute for Clinical and Biomedical Research (ICBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
- Luis Taborda-Barata
- Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal
- Rita Amaral
- MEDCIDS – Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
- Josep M. Antó
- ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain
- Anna Bedbrook
- ARIA, Montpellier, France
- Wienczyslawa Czarlewski
- ARIA, Montpellier, France
- Ignacio J. Ansotegui
- Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
- Karl-C Bergmann
- Institute of Allergology Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
- Matteo Bonini
- Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
- Apostolos Bossios
- Severe Asthma Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
- Louis-Philippe Boulet
- Quebec Heart and Lung Institute, Laval University, Québec City, Québec, Canada
- Fulvio Braido
- Respiratory and Allergy Clinic, IRCCS – Policlinico San Martino, Genoa, Italy
- Christopher Brightling
- Institute for Lung Health, Leicester NIHR BRC, University of Leicester, UK
- Guy Brusselle
- Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
- Luisa Brussino
- Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy
- G. Walter Canonica
- Asthma and Allergy Unit-IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- Alvaro A. Cruz
- Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
- Tari Haahtela
- Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, UK
- Liam G. Heaney
- Plymouth University, Plymouth, UK
- Michael Hyland
- Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
- Juan Carlos Ivancevich
- Department of Otolaryngology Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany
- Ludger Klimek
- Center for Rhinology and Allergology, Wiesbaden, Germany
- Marek Kulus
- Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
- Piotr Kuna
- Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
- Maciej Kupczyk
- Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
- Desiree E. Larenas-Linnemann
- Allergy Unit “D Kalogeromitros”, 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, ‘Attikon’ University Hospital institution institution, Athens, Greece
- Michael Makris
- Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
- Manuel Marques-Cruz
- MEDCIDS – Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
- Sara Gil-Mata
- MEDCIDS – Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
- Mário Morais-Almeida
- Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
- Marek Niedoszytko
- Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg
- Markus Ollert
- Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark
- Nikolaos G. Papadopoulos
- Division of Allergy and Clinical Immunology, Department of Medicine, “Santa Maria della Speranza” Hospital, Salerno, Italy
- Vincenzo Patella
- Agency of Health ASL, Salerno, Italy
- Oliver Pfaar
- Department of Respiratory and Infectious Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
- Celeste Porsbjerg
- Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain
- Francesca Puggioni
- Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil
- Santiago Quirce
- Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
- Carlos Robalo Cordeiro
- Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris, France
- Nicolas Roche
- UMR 1016, Institut Cochin, Paris, France
- Boleslaw Samolinski
- PROMISE Department, University of Palermo, Palermo, Italy
- Joaquin Sastre
- Department of Pulmonary Diseases and Allergy, Ljubljana University Medical Centre, Ljubljana, Slovenia
- Nicola Scichilone
- Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
- Sabina Skrgat
- Department of Otorhinolaryngology, University of Eastern Finland and the North Savo wellbeing services county, Kuopio, Finland
- Sanna Toppila-Salmi
- Royal Brompton Hospital, Airways Disease Section, London, UK
- Omar S. Usmani
- National Health and Lung Institute (NHLI), Imperial College London, London, UK
- Arunas Valiulis
- Department of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, Lithuania
- Brigita Gradauskiene
- Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy
- Ilgim Vardaloğlu Koyuncu
- Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Istanbul, Turkey
- Maria Teresa Ventura
- Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
- Rafael José Vieira
- MEDCIDS – Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
- Arzu Yorgancioglu
- Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw institution, Warsaw, Poland
- João A. Fonseca
- MEDCIDS – Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
- Torsten Zuberbier
- Institute of Allergology Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
- Benoit Pétré
- Department of Public Health, University of Liège, Liège, Belgium
- Renaud Louis
- GIGA I3 Research Group, University of Liège, Liège, Belgium
- Jean Bousquet
- ARIA, Montpellier, France
- DOI
- https://doi.org/10.1080/25310429.2025.2532980
- Journal volume & issue
-
Vol. 31,
no. 1
Abstract
Background and Research question We aimed to assess whether levels of digital biomarkers can reflect monthly patterns of asthma controlStudy design and methods We performed a longitudinal study on patients with asthma and comorbid rhinitis who filled ≥26 days of data in a month in the MASK-air® app and who reported at least 1 day of treatment with an inhaled corticosteroid with or without a long-acting β2-agonist (ICS ± LABA). We applied k-means cluster analysis to define clusters of months according to daily asthma control and medication use. Clusters were compared using digital biomarkers (visual analogue scale [VAS] on asthma symptoms and electronic daily asthma control score [e-DASTHMA]). We compared patients who did not switch with patients who switched their ICS ± LABA.Results We assessed 243 patients and 1358 months. We identified three clusters of poor asthma control despite high ICS ± LABA adherence, one cluster of poor asthma control and poor ICS ± LABA adherence, one cluster of good asthma control and high ICS ± LABA adherence and one cluster of good asthma control despite poor ICS ± LABA adherence. These clusters displayed relevant differences in VAS asthma and e-DASTHMA levels. Similar clusters were found in ‘non-switchers’ versus ‘switchers’.Conclusion Levels of digital biomarkers reflect asthma control patterns and might be used to monitor patients with asthma.
Keywords
