Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors

Libor Velíšek; Jana Velíšková; Teresa Ravizza; Filippo S. Giorgi; Solomon L. Moshé

doi:10.1016/j.nbd.2004.10.012

Neurobiology of Disease (Mar 2005)

Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors

Libor Velíšek,
Jana Velíšková,
Teresa Ravizza,
Filippo S. Giorgi,
Solomon L. Moshé

Affiliations

Libor Velíšek: Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Einstein/Montefiore Epilepsy Management Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Corresponding author. Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA. Fax: +1 718 430 8899.
Jana Velíšková: Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Einstein/Montefiore Epilepsy Management Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Teresa Ravizza: Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Einstein/Montefiore Epilepsy Management Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Filippo S. Giorgi: Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Einstein/Montefiore Epilepsy Management Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Solomon L. Moshé: Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Einstein/Montefiore Epilepsy Management Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA; Department of Pediatrics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA

DOI: https://doi.org/10.1016/j.nbd.2004.10.012
Journal volume & issue: Vol. 18, no. 2
pp. 346 – 355

Abstract

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Repetitive behaviors (such as circling) are one of the defining features of autism. The substantia nigra (SN) is involved in circling. We used unilateral SN pars reticulata (SNR) infusions of the GABA agonist muscimol to induce circling and deoxyglucose autoradiography mapping in adult and postnatal day (PN) 15 male and female rats to determine its substrates. In adults, muscimol infusions in posterior SNR induced a higher circling rate than in anterior SNR, after which males displayed faster circling than females. In contrast, PN15 female rats circled faster than PN15 male rats. Autoradiograms demonstrated age- and sex-specific alterations of deoxyglucose uptake in the SN pars compacta (SNC) associated with highest circling rates. The data suggest that there is a close relationship of the GABAergic SNR and dopaminergic SNC in the induction of circling; there is a topographic organization of the SNR in terms of circling behavior and associated deoxyglucose uptake, which is dependent on age and sex.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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