Российский кардиологический журнал (Dec 2017)

PREDICTIVE VALUE OF ERYTHROCYTE ANISOTROPY COEFFICIENT IN PATIENTS HOSPITALIZED FOR ACUTELY DECOMPENSATED CHRONIC HEART FAILURE

  • V. A. Kostenko,
  • M. Yu. Sitnikova,
  • Е. A. Skorodumova,
  • Е. G. Skorodumova,
  • A. N. Fedorov

DOI
https://doi.org/10.15829/1560-4071-2017-12-26-30
Journal volume & issue
Vol. 0, no. 12
pp. 26 – 30

Abstract

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Aim. To evaluate the role of erythrocyte anisotropy (RDW) coefficient as a predictor of adverse outcome in acutely decompensated chronic heart failure (ADCHF).Material and methods. Totally, 422 patients, age 37-82 y. o. (mean 66,8±2,3 y. o.) investigated, who had been hospitalized for ADCHF of ischemic origin with decreased ejection fraction (EFLV). All participants underwent routine tests, including the coefficient of erythrocyte anisotropy variation (RDW-CV, RDW-SD), C-reactive peptide (CRP) and brain natriuretic peptide (BNP). Instrumental methods included echocardiography in Mand B-regimens with EFLV measurement. Follow-up in 24 months was done via phone calls with the patient or relatives, and original questionnaire.Results. At admittance, mean values of RDW-CV were 16,3±2,9%, at discharge — 16,7±3,3%; RDW-SD — 48,7±7,3 fL and 53,6±8,7 fL, respectively. T-test for the relation of these two parameters with fatal outcome showed that only RDW-SD is significantly (p=0,045) relevant, for the period 24 months post discharge. Main group was separated to two subgroups — А (RDW-SD <46,5 fL (n=173)), and B (RDW-SD ≥46,5 fL (n=249)). In aspect of the adverse outcome, group comparison with T-criteria by Student was 6,9 (p=0,0001). There was direct correlation of average strength between hemoglobin contents (r=0,53, р<0,05), creatinine (r=0,55, р<0,05) and С-reactive protein (CRP) (r=0,35; р>0,05), negative correlation for EFLV (r=-0,54, p<0,05) with RDW-SD.Conclusion. In ADCHF patients the RDW-SD parameter seems to be more significant than RDW-CV in relevance to prediction, and its values correlate with CRP, hemoglobin, creatinine, as negatively also correlate with EFLV. The RDW-SD value higher than 46,5 fL, regardless the other factors, significantly predicts the increase of patients mortality after ADCHF.Russ J Cardiol 2017, 12 (152): 26–30 http://dx.doi.org/10.15829/1560-4071-2017-12-26-30

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