Journal of Isotopes (Feb 2014)

Syntheses of Stable Isotope Labeled D12-Malachite Green

  • YANG Chao;YANG Wei-cheng;LI Mei-hua;LUO Yong

DOI
https://doi.org/10.7538/tws.2014.27.02.0077
Journal volume & issue
Vol. 27, no. 2
pp. 77 – 81

Abstract

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The efficient synthesis of stable isotope labeled D12-Malachite Green with CD3OD as the precursor by methylation, condensation and oxidation was presented. The yields of D12-Malachite Green was 50.1 % based on CD3OD consumed. The product was ideatified by HPLC, MS, and NMR to be the target compound. Its chemical purity and isotopic enrichment were higher than 99.0 atom%D. The result showed that the D12-Malachite Green could be used as internal standard in the field of food safety.

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