Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V.
Christian Grah,
Shiao Li Oei,
Joanna Krist,
Björn Wiesemann,
Bernd Schmidt,
Andreas Fertl,
Björn Schwick,
Ralf-Harto Hübner,
Birgit Becke,
Karl-Josef Franke,
Christian Geltner,
Stephan Eisenmann,
Franz Stanzel,
Grit Barten-Neiner,
Thomas Sgarbossa,
Katarzyna Blazejczyk,
Hannah Wüstefeld
Affiliations
Christian Grah
Department of Respiratory Medicine, Clinic Havelhöhe Berlin, Berlin, Germany
Shiao Li Oei
Research Institute Havelhöhe, Clinic Havelhöhe Berlin, Berlin, Germany
Joanna Krist
Department of Respiratory Medicine, Lung Clinic Heckeshorn, Helios Klinikum Emil von Behring, Berlin, Germany
Björn Wiesemann
Center of Respiratory Medicine, Lung Clinic Immenhausen, Immenhausen, Germany
Bernd Schmidt
Department of Respiratory Medicine, DRK-Klinikum, Berlin-Mitte, Germany
Andreas Fertl
Department of Internal Medicine and Respiratory Medicine, Krankenhaus Martha-Maria München, München, Germany
Björn Schwick
Department of Respirartory Medicine, Luisenhospital Aachen, Germany
Ralf-Harto Hübner
Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Birgit Becke
Department of Respiratory Medicine, Johanniter-Krankenhaus Treuenbrietzen, Treuenbrizen, Germany
Karl-Josef Franke
Department of Respiratory Medicine and Critical Care Medicine, Klinikum Lüdenscheid and Witten/Herdecke University, Witten, Germany
Christian Geltner
Department of Respiratory Medicine, Donau-Isar-Klinikum, Germany
Stephan Eisenmann
Department of Respiratory Medicine, Universitätsklinikum Halle, Halle, Germany
Franz Stanzel
Department of Respiratory Medicine, Lungenklinik Hemer, Hemer, Germany
Grit Barten-Neiner
CAPNETZ STIFTUNG, Hannover, Germany
Thomas Sgarbossa
Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Katarzyna Blazejczyk
Department of Respiratory Medicine, Clinic Havelhöhe Berlin, Berlin, Germany
Hannah Wüstefeld
Department of Respiratory Medicine, Clinic Havelhöhe Berlin, Berlin, Germany
Background Clinical trials have shown beneficial results from lung volume reduction with endobronchial coils in patients with emphysema, but comprehensive safety data are not yet available for a new coil type, Coil #4. The objective of this study is to generate real-world data (RWD) on the safety and efficacy of endobronchial Coil #2 and Coil #4.Methods This is a cohort study of prospectively collected data from the multicenter German Lung Emphysema Registry e.V. (LE-Registry) for patients with advanced lung emphysema undergoing lung volume reduction. All patients treated with Coil #2 or Coil #4 were evaluated at baseline and at 3 months for pulmonary function tests (FEV1, FVC, RV, DLCO, pCO2), exercise capacity, quality of life (mMRC, CAT, SGRQ), and adverse events. Descriptive statistics were used to analyze response rates and changes in clinical outcomes.Results Data from 73 patients (37 Coil #2, 36 Coil #4) enrolled between 2017 and 2024 were evaluated. At 3 months, outcome data were available for 32 Coil #2 and 26 Coil #4 patients. In the Coil #2 cohort significant improvements in RV and SGRQ were observed. The Coil #4 cohort shows significant improvements in FVC, RV, SGRQ, and CAT. Complications occurred in 37% of Coil #2 and 37% of Coil #4 patients, with 26% of patients treated with Coil #4 experiencing pneumothorax.Conclusions The outcomes observed in this RWD study are consistent with other published coil studies. The higher pneumothorax rate with Coil #4 is surprising and should be minimized by adapting the technique.Trial registration DRKS00021207 registered on 29/05/2020.
