Thrombotic Microangiopathy in Pregnancy: Current Understanding and Management Strategies

Abstract

Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by microvascular thrombosis and end-organ damage. Pregnancy-associated thrombotic microangiopathy (p-TMA) has emerged as a distinct clinical entity with unique diagnostic challenges. Identifying the specific form of p-TMA is critical for appropriate and timely management. This review offers a comprehensive overview of the various forms of thrombotic microangiopathies associated with pregnancy, highlighting our current understanding of their pathophysiology and the evolving landscape of diagnosis and treatment for each.

Keywords

• complement
• microangiopathic hemolytic anemia
• pregnancy
• thrombocytopenia
• thrombotic microangiopathy